8-Bromo-6-fluoroquinoline

Name: 8-Bromo-6-fluoroquinoline
Brand: ChemScene
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CAS No. 22960-18-5
Cat. No. CS-0155678
Purity≥97%
MDL No.MFCD09907837

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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General Information

CAS No. 22960-18-5
Cat. No. CS-0155678
Purity ≥97%
MDL No. MFCD09907837
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₉H₅BrFN
Molecular Weight 226.05
Synonym(s) None
SMILES C1=CC2=CC(=CC(=C2N=C1)Br)F

Description

8-Bromo-6-fluoroquinoline features a fused bicyclic core with strategically positioned halogen substituents, enabling precise functionalization in transition-metal-catalyzed coupling reactions. The electron-deficient quinoline framework enhances reactivity in cross-coupling processes, while the bromine and fluorine atoms offer orthogonal handles for sequential derivatization. This compound serves as a key building block in the synthesis of advanced pharmaceutical intermediates and functional materials.

Application

8-Bromo-6-fluoroquinoline serves as a versatile heterocyclic building block in medicinal chemistry, enabling direct functionalization at multiple sites due to its complementary halogen reactivity. The bromo group facilitates palladium-catalyzed cross-coupling, while the fluoro substituent supports nucleophilic aromatic substitution under mild conditions. This dual functionality enhances synthetic flexibility for constructing complex scaffolds. Its bench-stable crystalline form simplifies handling and purification in routine synthesis workflows.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H320-H335
Precautionary Statements : P261-P280-P302+P352

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Computational Chemistry Data

TPSA 12.89
LogP 3.1364
H_Acceptors 1
H_Donors 0
Rotatable_Bonds 0

Other Classifications

Building Blocks Functional Group Bromide

Building Blocks Skeleton Aromatic heterocycle compounds quinoline compounds

Key Words

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8-Bromo-6-fluoroquinoline

CAS No. 22960-18-5

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