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CS-W001157 4
Total: USD 88.00

2-(4-Sulfamoylphenyl)acetic acid

  • CAS No. 22958-64-1

  • Cat. No. CS-0129490
  • Purity≥95%
  • MDL No.MFCD07801100

*For research and further manufacturing use only, not for direct human use.

2-(4-Sulfamoylphenyl)acetic acid|CS-0129490

Structure of 22958-64-1

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General Information

  • CAS No. 22958-64-1
  • Cat. No. CS-0129490
  • Purity ≥95%
  • MDL No. MFCD07801100
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₉NO₄S
  • Molecular Weight 215.23
  • Synonym(s) (4-Sulfamoyl-phenyl)-acetic acid
  • SMILES O=C(O)CC1=CC=C(S(=O)(N)=O)C=C1

Description

This sulfonamide-containing acetic acid derivative integrates a polar, electron-withdrawing sulfamoyl group with a flexible acetyl side chain. The para-substituted phenyl scaffold enhances solubility and metabolic stability, making it suitable for medicinal chemistry campaigns targeting kinase inhibition and protein-protein interactions.

Application

2-(4-Sulfamoylphenyl)acetic acid serves as a versatile building block for sulfonamide-containing aromatic systems, enabling efficient access to biologically relevant scaffolds. Its carboxylic acid functionality facilitates direct amidation, esterification, or coupling reactions, while the para-sulfamoyl group offers enhanced solubility and metabolic stability. The molecule exhibits good bench stability and is readily purified by crystallization, making it well-suited for medicinal chemistry campaigns and API intermediate synthesis.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   97.46
  • LogP   -0.0389
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   3

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