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CS-W001157 4
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(4S,4'S,5R,5'R)-2,2'-Cyclopropylidenebis[4,5-dihydro-4,5-diphenyloxazole]

  • CAS No. 229184-97-8

  • Cat. No. CS-0103899
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

(4S,4'S,5R,5'R)-2,2'-Cyclopropylidenebis[4,5-dihydro-4,5-diphenyloxazole]|CS-0103899

Structure of 229184-97-8

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General Information

  • CAS No. 229184-97-8
  • Cat. No. CS-0103899
  • Purity ≥97%
  • MDL No. None
  • Storage -20°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₃₃H₂₈N₂O₂
  • Molecular Weight 484.59
  • Synonym(s) None
  • SMILES C1(C2(C3=N[C@@H](C4=CC=CC=C4)[C@@H](C5=CC=CC=C5)O3)CC2)=N[C@@H](C6=CC=CC=C6)[C@@H](C7=CC=CC=C7)O1

Description

This chiral oxazole dimer features a rigid cyclopropylidene bridge that enforces a defined spatial arrangement, enabling precise stereocontrol in asymmetric synthesis. The diphenyl-substituted oxazole rings provide enhanced stability and solubility in organic media, facilitating use in catalytic applications.

Application

(4S,4'S,5R,5'R)-2,2'-Cyclopropylidenebis[4,5-dihydro-4,5-diphenyloxazole] serves as a chiral, rigid bis-oxazole scaffold enabling asymmetric synthesis of complex heterocyclic systems. Its defined stereochemistry and stability under standard reaction conditions facilitate predictable coupling reactions, while the diphenyl-substituted oxazole rings offer enhanced functional group tolerance and ease of purification. This compound functions effectively in transition metal-catalyzed transformations and acts as a valuable building block for medicinal chemistry campaigns requiring conformationally constrained architectures.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   43.18
  • LogP   8.2253
  • H_Acceptors   4
  • H_Donors   0
  • Rotatable_Bonds   6

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