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CS-W001157 4
Total: USD 88.00

Ethyl 2-bromo-4-methylthiazole-5-carboxylate

  • CAS No. 22900-83-0

  • Cat. No. CS-W007525
  • Purity≥96%
  • MDL No.MFCD03791227

*For research and further manufacturing use only, not for direct human use.

Ethyl 2-bromo-4-methylthiazole-5-carboxylate|CS-W007525

Structure of 22900-83-0

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General Information

  • CAS No. 22900-83-0
  • Cat. No. CS-W007525
  • Purity ≥96%
  • MDL No. MFCD03791227
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₈BrNO₂S
  • Molecular Weight 250.11
  • Synonym(s) 2-Bromo-4-methylthiazole-5-carboxylic Acid Ethyl Ester
  • SMILES O=C(C1=C(C)N=C(Br)S1)OCC

Description

Ethyl 2-bromo-4-methylthiazole-5-carboxylate is a bench-stable, moisture-tolerant heterocyclic building block featuring a brominated thiazole core. This compound integrates readily into cross-coupling reactions and serves as a key intermediate for synthesizing bioactive thiazole derivatives in medicinal chemistry and agrochemical development.

Application

Ethyl 2-bromo-4-methylthiazole-5-carboxylate serves as a versatile building block in heterocyclic synthesis, enabling efficient access to thiazole-based scaffolds prevalent in medicinal chemistry. The bromo group facilitates palladium-catalyzed cross-coupling reactions, while the ester functionality supports selective reduction and derivatization. Its bench-stable nature and compatibility with standard reaction conditions make it ideal for modular synthesis workflows.

Synthesis

  • Route1

    References

    • GLAXO GROUP LIMITED Patent: WO2004/6924 A1, 2004 ; Location in patent: Page/Page column 31-32 ;
  • Route2
    • In-stock
      Ethyl 2-amino-4-methylthiazole-5-carboxylate|CS-W002386
      7210-76-6
    • null|null
      110-46-3
    • ~71%
    • In-stock
      Ethyl 2-bromo-4-methylthiazole-5-carboxylate|CS-W007525
      22900-83-0

    References

    • GLAXO GROUP LIMITED Patent: WO2004/6922 A1, 2004 ; Location in patent: Page/Page column 34; 35 ;
  • Route3

    References

    • WO2011/73617 A1, ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05,GHS07
Signal Word : Danger
UN#: 1759
Class : 8
Packing Group : Ⅲ
Hazard Statements : H315-H317-H318-H335
Precautionary Statements : P261-P264-P271-P272-P280-P302+P352-P304+P340-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   39.19
  • LogP   2.39072
  • H_Acceptors   4
  • H_Donors   0
  • Rotatable_Bonds   2

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