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CS-W001157 4
Total: USD 88.00

4-(Trifluoromethyl)-N-methylaniline

  • CAS No. 22864-65-9

  • Cat. No. CS-M1968
  • Purity≥96%
  • MDL No.MFCD07369717

*For research and further manufacturing use only, not for direct human use.

4-(Trifluoromethyl)-N-methylaniline|CS-M1968

Structure of 22864-65-9

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General Information

  • CAS No. 22864-65-9
  • Cat. No. CS-M1968
  • Purity ≥96%
  • MDL No. MFCD07369717
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₈F₃N
  • Molecular Weight 175.15
  • Synonym(s) N-methyl-4-(trifluoromethyl)-benzenamine
  • SMILES FC(C1=CC=C(NC)C=C1)(F)F

Description

4-(Trifluoromethyl)-N-methylaniline features a trifluoromethyl group that imparts strong electron-withdrawing character, enhancing reactivity in electrophilic substitution. The N-methyl substitution improves solubility and metabolic stability, making this compound valuable for pharmaceutical intermediates and agrochemical synthesis.

Application

4-(Trifluoromethyl)-N-methylaniline serves as a valuable building block in medicinal chemistry, enabling the introduction of both electron-withdrawing trifluoromethyl and amine functionalities in a single scaffold. Its stability under standard reaction conditions facilitates diverse transformations, including electrophilic substitution and coupling reactions, while the N-methyl group enhances metabolic stability and membrane permeability—key attributes for bioactive compound development.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H317
Precautionary Statements : P261-P264-P270-P272-P280-P302+P352-P330-P362+P364-P501

Quality Control

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Computational Chemistry Data

  • TPSA   12.03
  • LogP   2.7471
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   1

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