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CS-W001157 4
Total: USD 88.00

1-(2-Hydroxy-4-trifluoromethyl-phenyl)-ethanone

  • CAS No. 228572-69-8

  • Cat. No. CS-0211752
  • Purity≥98%
  • MDL No.MFCD09754177

*For research and further manufacturing use only, not for direct human use.

1-(2-Hydroxy-4-trifluoromethyl-phenyl)-ethanone|CS-0211752

Structure of 228572-69-8

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General Information

  • CAS No. 228572-69-8
  • Cat. No. CS-0211752
  • Purity ≥98%
  • MDL No. MFCD09754177
  • Storage RT, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₇F₃O₂
  • Molecular Weight 204.15
  • Synonym(s) 1-(2-Hydroxy-4-(trifluoromethyl)phenyl)ethanone
  • SMILES CC(=O)C1=C(C=C(C=C1)C(F)(F)F)O

Description

This ketone features a trifluoromethyl-substituted phenyl ring linked to an acetyl group, delivering enhanced electron-withdrawing character and improved metabolic stability. The ortho-hydroxyl group enables intramolecular hydrogen bonding, increasing rigidity and influencing reactivity in synthetic transformations. Ideal for constructing complex heterocycles and functionalized scaffolds in medicinal chemistry and materials science applications.

Application

1-(2-Hydroxy-4-trifluoromethyl-phenyl)-ethanone serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocycles and pharmaceutical intermediates. Its trifluoromethyl group enhances metabolic stability and modulates lipophilicity, while the phenolic hydroxyl and ketone functionalities offer orthogonal handles for derivatization. The compound exhibits good bench stability and facilitates efficient functional group transformations in standard synthetic workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   37.3
  • LogP   2.6136
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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