tert-Butyl 3,7-diazabicyclo[3.3.1]nonane-3-carboxylate

Name: tert-Butyl 3,7-diazabicyclo[3.3.1]nonane-3-carboxylate
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 227940-72-9
Cat. No. CS-0036855
Purity≥95%
MDL No.MFCD17016673

HazMat Fee +

HazMat Fee

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

The shipment is processed through FedEx Ground under the Limited Quantity option.

Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

tert-Butyl 3,7-diazabicyclo[3.3.1]nonane-3-carboxylate|CS-0036855

Structure of 227940-72-9

Size

Price

Quantity

* Please select Quantity before adding items.

General Information

CAS No. 227940-72-9
Cat. No. CS-0036855
Purity ≥95%
MDL No. MFCD17016673
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₂H₂₂N₂O₂
Molecular Weight 226.32
Synonym(s) tert-butyl 8-{3,7-diazabicyclo[3.3.1]nonan-1-yl}-2-ethyloctanoate
SMILES CC(C)(C)OC(=O)N1CC2CC(CNC2)C1

Description

tert-Butyl 3,7-diazabicyclo[3.3.1]nonane-3-carboxylate is a bench-stable, moisture-tolerant heterocyclic scaffold featuring a rigid bicyclic core with strategically positioned nitrogen atoms. This tertiary amine functionality enables efficient coupling reactions and facilitates incorporation into complex molecular architectures. The tert-butyl ester group offers convenient protection and orthogonal deprotection under mild acidic conditions, streamlining synthetic access to bioactive amines.

Application

tert-Butyl 3,7-diazabicyclo[3.3.1]nonane-3-carboxylate serves as a versatile scaffold for medicinal chemistry and catalysis, enabling the construction of constrained bicyclic amines with defined stereochemistry. The protected amine functionality offers excellent bench stability, facilitates straightforward purification, and enables selective deprotection or functionalization in multi-step syntheses. Its rigid framework provides favorable conformational control in ligand and drug discovery applications.

Synthesis

Route1
- In-stock
  
  227940-71-8
- ~94%
- In-stock
  
  227940-72-9
References
- TARGACEPT, INC. Patent: WO2009/111550 A1, 2009 ; Location in patent: Page/Page column 38 ;
Route2
- In-stock
  
  227940-70-7
- ~%
- In-stock
  
  227940-72-9
References
- ACTELION PHARMACEUTICALS LTD; BOSS, Christoph; BROTSCHI, Christine; HEIDMANN, Bibia; SIFFERLEN, Thierry; WILLIAMS, Jodi, T. Patent: WO2013/50938 A1, 2013 ;

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

TPSA 41.57
LogP 1.4628
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 0

Other Classifications

Building Blocks Skeleton Aliphatic heterocycle compounds Piperidine compounds

Building Blocks Skeleton Bridge Rings compounds Other bridge ring compounds

Key Words

227940-72-9 sigma227940-72-9 manufacturer227940-72-9 price227940-72-9 structure227940-72-9 SDSbuy 227940-72-9227940-72-9 supplier227940-72-9 uses227940-72-9 molecular weightprice of 227940-72-9227940-72-9 chemical name formula of 227940-72-9

Salutation:	*Country or Region:
*Applicant Name:	*Organization Name:
*Email Address:	Quantity:
CAS NO. :	Product Name:
Remarks:
Upload Pictures

CAS.No.		Product Name
Applicant Name *		Email Address *
Phone Number *		Organization Name*
Country or Region*		Quantity*
Remarks:

Product Name:
Cat. No.: .		CAS NO. :
Quantity:

tert-Butyl 3,7-diazabicyclo[3.3.1]nonane-3-carboxylate

CAS No. 227940-72-9

Recommended Products