7-Chloroquinolin-2(1H)-one

Name: 7-Chloroquinolin-2(1H)-one
Brand: ChemScene
Availability: InStock
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CAS No. 22614-72-8
Cat. No. CS-W006065
Purity≥95%
MDL No.MFCD08460109

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

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Structure of 22614-72-8

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Description

7-Chloroquinolin-2(1H)-one features a chlorine-substituted quinoline core with a lactam functionality, delivering enhanced electron-withdrawing character and improved solubility in polar solvents. This scaffold serves as a key building block for medicinal chemistry campaigns targeting kinase inhibitors and antiparasitic agents, offering robust stability under standard bench conditions.

Application

7-Chloroquinolin-2(1H)-one serves as a versatile scaffold for medicinal chemistry and materials science, enabling efficient derivatization at the C-3 position via nucleophilic substitution or transition-metal-catalyzed coupling. Its inherent stability, solubility in common organic solvents, and compatibility with diverse functional groups make it well-suited for high-throughput synthesis of quinolinone-based libraries. The chlorine substituent enhances electrophilicity for further functionalization, while the lactam moiety provides a rigid, planar framework ideal for target-directed design.

General Information

CAS No. 22614-72-8
Cat. No. CS-W006065
Purity ≥95%
MDL No. MFCD08460109
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₉H₆ClNO
Molecular Weight 179.60
Synonym(s) 7-Chloro-2-hydroxyquinoline
SMILES O=C1NC2=C(C=CC(Cl)=C2)C=C1

Computational Chemistry Data

TPSA 32.86
LogP 2.1815
H_Acceptors 1
H_Donors 1
Rotatable_Bonds 0

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Other Classifications

Building Blocks Skeleton Aromatic heterocycle compounds quinoline compounds

Key Words

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7-Chloroquinolin-2(1H)-one

CAS No. 22614-72-8

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