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CS-W001157 4
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(3S)-tert-Butyl 4-(6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-(2-isopropyl-4-methylpyridin-3-yl)-2-oxo-1,2-dihydropyrido[2,3-d]pyrimidin-4-yl)-3-methylpiperazine-1-carboxylate

  • CAS No. 2252403-85-1

  • Cat. No. CS-0376818
  • Purity≥96%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

(3S)-tert-Butyl 4-(6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-(2-isopropyl-4-methylpyridin-3-yl)-2-oxo-1,2-dihydropyrido[2,3-d]pyrimidin-4-yl)-3-methylpiperazine-1-carboxylate|CS-0376818

Structure of 2252403-85-1

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General Information

  • CAS No. 2252403-85-1
  • Cat. No. CS-0376818
  • Purity ≥96%
  • MDL No. None
  • Storage 4°C, protect from light, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₃₂H₃₆F₂N₆O₄
  • Molecular Weight 606.66
  • Synonym(s) None
  • SMILES O=C1N(C2=C(N=CC=C2C)C(C)C)C3=NC(C4=C(C=CC=C4O)F)=C(F)C=C3C(N5[C@H](CN(CC5)C(OC(C)(C)C)=O)C)=N1

Description

This piperazine-based scaffold integrates a fluorinated pyrido[2,3-d]pyrimidine core with a hydroxyaryl substituent and a sterically hindered tert-butyl ester, enabling targeted engagement in kinase inhibition studies.

Application

(3S)-tert-Butyl 4-(6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-(2-isopropyl-4-methylpyridin-3-yl)-2-oxo-1,2-dihydropyrido[2,3-d]pyrimidin-4-yl)-3-methylpiperazine-1-carboxylate serves as a key intermediate in the synthesis of advanced pyrido[2,3-d]pyrimidine-based scaffolds. Its structure combines a fluorinated aryl moiety, a piperazine linker, and a stable tert-butyl ester, enabling selective deprotection and functionalization. The compound exhibits bench stability and facilitates efficient coupling reactions, supporting scalable access to bioactive heterocycles in medicinal chemistry programs.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   113.68
  • LogP   5.70392
  • H_Acceptors   9
  • H_Donors   1
  • Rotatable_Bonds   4

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