(3S)-tert-Butyl 4-(6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-(2-isopropyl-4-methylpyridin-3-yl)-2-oxo-1,2-dihydropyrido[2,3-d]pyrimidin-4-yl)-3-methylpiperazine-1-carboxylate

Name: (3S)-tert-Butyl 4-(6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-(2-isopropyl-4-methylpyridin-3-yl)-2-oxo-1,2-dihydropyrido[2,3-d]pyrimidin-4-yl)-3-methylpiperazine-1-carboxylate
Brand: ChemScene
Availability: InStock
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CAS No. 2252403-85-1
Cat. No. CS-0376818
Purity≥96%
MDL No.None

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(3S)-tert-Butyl 4-(6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-(2-isopropyl-4-methylpyridin-3-yl)-2-oxo-1,2-dihydropyrido[2,3-d]pyrimidin-4-yl)-3-methylpiperazine-1-carboxylate|CS-0376818

Structure of 2252403-85-1

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Description

This piperazine-based scaffold integrates a fluorinated pyrido[2,3-d]pyrimidine core with a hydroxyaryl substituent and a sterically hindered tert-butyl ester, enabling targeted engagement in kinase inhibition studies.

Application

(3S)-tert-Butyl 4-(6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-(2-isopropyl-4-methylpyridin-3-yl)-2-oxo-1,2-dihydropyrido[2,3-d]pyrimidin-4-yl)-3-methylpiperazine-1-carboxylate serves as a key intermediate in the synthesis of advanced pyrido[2,3-d]pyrimidine-based scaffolds. Its structure combines a fluorinated aryl moiety, a piperazine linker, and a stable tert-butyl ester, enabling selective deprotection and functionalization. The compound exhibits bench stability and facilitates efficient coupling reactions, supporting scalable access to bioactive heterocycles in medicinal chemistry programs.

General Information

CAS No. 2252403-85-1
Cat. No. CS-0376818
Purity ≥96%
MDL No. None
Storage 4°C, protect from light, stored under nitrogen
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₃₂H₃₆F₂N₆O₄
Molecular Weight 606.66
Synonym(s) None
SMILES O=C1N(C2=C(N=CC=C2C)C(C)C)C3=NC(C4=C(C=CC=C4O)F)=C(F)C=C3C(N5[C@H](CN(CC5)C(OC(C)(C)C)=O)C)=N1

Computational Chemistry Data

TPSA 113.68
LogP 5.70392
H_Acceptors 9
H_Donors 1
Rotatable_Bonds 4

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Other Classifications

Building Blocks Functional Group Fluoride

Building Blocks Skeleton Aromatic heterocycle compounds Other aromatic heterocycles compounds

Building Blocks Skeleton Aliphatic heterocycle compounds Piperidine compounds

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

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(3S)-tert-Butyl 4-(6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-(2-isopropyl-4-methylpyridin-3-yl)-2-oxo-1,2-dihydropyrido[2,3-d]pyrimidin-4-yl)-3-methylpiperazine-1-carboxylate

CAS No. 2252403-85-1

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