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CS-W001157 4
Total: USD 88.00

Ethyl 4-methylpiperidine-4-carboxylate hydrochloride

  • CAS No. 225240-71-1

  • Cat. No. CS-W003758
  • Purity≥97%
  • MDL No.MFCD11045418

*For research and further manufacturing use only, not for direct human use.

Ethyl 4-methylpiperidine-4-carboxylate hydrochloride|CS-W003758

Structure of 225240-71-1

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General Information

  • CAS No. 225240-71-1
  • Cat. No. CS-W003758
  • Purity ≥97%
  • MDL No. MFCD11045418
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₈ClNO₂
  • Molecular Weight 207.70
  • Synonym(s) ethyl 4-methylpiperidine-4-carboxylate monohydrochloride
  • SMILES CCOC(=O)C1(C)CCNCC1.Cl

Description

Ethyl 4-methylpiperidine-4-carboxylate hydrochloride features a tertiary amine center flanked by an ester group and a methyl substituent, delivering enhanced solubility and stability under standard conditions. This bench-stable salt form facilitates efficient incorporation into synthetic sequences requiring nitrogen-directed functionalization or cyclization cascades.

Application

Ethyl 4-methylpiperidine-4-carboxylate hydrochloride serves as a versatile building block in medicinal chemistry, enabling efficient access to piperidine-based scaffolds. The protected amine and ester functionalities offer orthogonal reactivity, facilitating downstream transformations such as amidation, reduction, or coupling reactions. Its crystalline form ensures ease of handling and purification, while the hydrochloride salt enhances stability and solubility in common organic solvents, making it well-suited for scale-up and routine synthesis workflows.

Synthesis

  • Route1

    References

    • WO2006/83003 A1, ; Page/Page column 37 ;
  • Route2

    References

    • US2012/88750 A1, ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   38.33
  • LogP   1.361
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   2

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