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4-(4-Chlorophenyl)pyrrolidin-2-one

  • CAS No. 22518-27-0

  • Cat. No. CS-0186869
  • Purity≥98%
  • MDL No.MFCD00854139

*For research and further manufacturing use only, not for direct human use.

4-(4-Chlorophenyl)pyrrolidin-2-one|CS-0186869

Structure of 22518-27-0

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General Information

  • CAS No. 22518-27-0
  • Cat. No. CS-0186869
  • Purity ≥98%
  • MDL No. MFCD00854139
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₀ClNO
  • Molecular Weight 195.65
  • Synonym(s) 4-(4-Chlorophenyl)-2-pyrrolidinone
  • SMILES ClC1=CC=C(C2CC(NC2)=O)C=C1

Description

0

Application

4-(4-Chlorophenyl)pyrrolidin-2-one serves as a versatile building block in medicinal chemistry, enabling the construction of biologically relevant heterocyclic scaffolds. Its bench-stable nature and tolerance to diverse functional groups facilitate straightforward incorporation into target molecules via standard coupling and reduction protocols. The chlorophenyl moiety provides a handle for further derivatization, enhancing its utility in the synthesis of pharmaceutical intermediates and API candidates.

Synthesis

  • Route1

    References

    • ARENA PHARMACEUTICALS, INC. Patent: WO2009/58300 A1, 2009 ; Location in patent: Page/Page column 77 ; WO 2009/058300 A1
  • Route2
    • 4-(4-Chlorophenyl)-1,5-dihydro-2H-pyrrol-2-one|CS-0970948
      81187-93-1
    • ~57%
    • In-stock
      4-(4-Chlorophenyl)pyrrolidin-2-one|CS-0186869
      22518-27-0

    References

    • Allan; Tran Australian Journal of Chemistry, 1981 , vol. 34, # 12 p. 2641 - 2645
  • Route3
    • null|null
      1267109-05-6
    • ~78%
    • In-stock
      4-(4-Chlorophenyl)pyrrolidin-2-one|CS-0186869
      22518-27-0

    References

    • Fryszkowska, Anna; Fisher, Karl; Gardiner, John M.; Stephens, Gill M. Organic and Biomolecular Chemistry, 2010 , vol. 8, # 3 p. 533 - 535

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS06
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H301
Precautionary Statements : P264-P270-P330-P405-P501

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Computational Chemistry Data

  • TPSA   29.1
  • LogP   1.9435
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   1

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