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CS-W001157 4
Total: USD 88.00

2,2'-(1,4-Phenylenebis(oxy))diacetic acid

  • CAS No. 2245-53-6

  • Cat. No. CS-W013773
  • Molecule weight226.18
  • Purity≥97%
  • MDL No.MFCD00016816

*For research and further manufacturing use only, not for direct human use.

2,2'-(1,4-Phenylenebis(oxy))diacetic acid|CS-W013773

Structure of 2245-53-6

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General Information

  • CAS No. 2245-53-6
  • Cat. No. CS-W013773
  • Purity ≥97%
  • MDL No. MFCD00016816
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₀O₆
  • Molecular Weight 226.18
  • Synonym(s) Hydroquinone-O,O-diacetic acid
  • SMILES O=C(O)COC1=CC=C(OCC(=O)O)C=C1

Description

DBCO-NHS Ester is a very popular amine-reactive click chemistry reagent. It can be used to modify an amine-containing molecule in organic solvents (limited solubility in aqueous media). It reacts with primary amines such as the side chain of lysine residues or aminosilane-coated surfaces at neutral or slightly basic pH to form covalent bonds. The low mass weight will add minimal spacer to modified molecules. DBCO is commonly used for copper-free Click Chemistry reactions.

Synthesis

  • Route1
    • null|null
      80791-19-1
    • ~65%
    • In-stock
      2,2'-(1,4-Phenylenebis(oxy))diacetic acid|CS-W013773
      2245-53-6

    References

    • Bezwada Biomedical, LLC Patent: US8053591 B2, 2011 ; Location in patent: Page/Page column 57-58 ;
  • Route2
    • null|null
      79-11-8
    • null|null
      123-31-9
    • ~88%
    • In-stock
      2,2'-(1,4-Phenylenebis(oxy))diacetic acid|CS-W013773
      2245-53-6

    References

    • Wei, Taibao; Chen, Jichou; Wang, Xicun; Zhang, Youming; Wang, Lailai Synthetic Communications, 1996 , vol. 26, # 7 p. 1447 - 1454
  • Route3
    • Diethyl 2,2'-(1,4-phenylenebis(oxy))diacetate|CS-0331691
      5897-78-9
    • ~93%
    • In-stock
      2,2'-(1,4-Phenylenebis(oxy))diacetic acid|CS-W013773
      2245-53-6

    References

    • Asakawa, Masumi; Ashton, Peter R.; Menzer, Stephan; Raymo, Francisco M.; Stoddart, J. Fraser; et al. Chemistry--A European Journal, 1996 , vol. 2, # 7 p. 877 - 893

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P264-P271-P302+P352-P362-P501

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Computational Chemistry Data

  • TPSA   93.06
  • LogP   0.6134
  • H_Acceptors   4
  • H_Donors   2
  • Rotatable_Bonds   6

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