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Structure of 2243565-12-8
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endo-BCN-PEG2-C2-NHS ester features a strained cyclooctyne warhead paired with a PEG2 spacer and C2 linker, enabling rapid, bioorthogonal conjugation via inverse electron-demand Diels-Alder reaction. This bench-stable reagent delivers efficient labeling of azide-functionalized biomolecules under physiological conditions.
endo-BCN-PEG2-C2-NHS ester serves as a versatile bifunctional linker for site-specific conjugation in bioorthogonal chemistry. The strained bicyclononyne (BCN) group enables rapid, selective cycloaddition with azides under physiological conditions, while the PEG2 spacer enhances solubility and reduces non-specific binding. The NHS ester reacts efficiently with primary amines, facilitating stable amide bond formation. This reagent combines excellent bench stability, straightforward purification, and broad functional group tolerance, making it ideal for labeling biomolecules, constructing drug conjugates, and developing targeted therapeutics.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
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Lot numbers can be found on the outside label of a product: