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CS-W001157 4
Total: USD 88.00

endo-BCN-PEG2-NHS ester

  • CAS No. 2243565-12-8

  • Cat. No. CS-0114297
  • Purity≥95%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

endo-BCN-PEG2-NHS ester|CS-0114297

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General Information

  • CAS No. 2243565-12-8
  • Cat. No. CS-0114297
  • Purity ≥95%
  • MDL No. None
  • Storage -20°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₂₂H₃₀N₂O₈
  • Molecular Weight 450.48
  • Synonym(s) None
  • SMILES O=C(CCC1=O)N1OC(CCOCCOCCNC(OCC2C3C2CCC#CCC3)=O)=O

Description

endo-BCN-PEG2-C2-NHS ester features a strained cyclooctyne warhead paired with a PEG2 spacer and C2 linker, enabling rapid, bioorthogonal conjugation via inverse electron-demand Diels-Alder reaction. This bench-stable reagent delivers efficient labeling of azide-functionalized biomolecules under physiological conditions.

Application

endo-BCN-PEG2-C2-NHS ester serves as a versatile bifunctional linker for site-specific conjugation in bioorthogonal chemistry. The strained bicyclononyne (BCN) group enables rapid, selective cycloaddition with azides under physiological conditions, while the PEG2 spacer enhances solubility and reduces non-specific binding. The NHS ester reacts efficiently with primary amines, facilitating stable amide bond formation. This reagent combines excellent bench stability, straightforward purification, and broad functional group tolerance, making it ideal for labeling biomolecules, constructing drug conjugates, and developing targeted therapeutics.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   120.47
  • LogP   1.1827
  • H_Acceptors   8
  • H_Donors   1
  • Rotatable_Bonds   12

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