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(R,E)-3-(1-Methylpyrrolidin-2-yl)acrylic acid hydrochloride

  • CAS No. 2243041-69-0

  • Cat. No. CS-0110890
  • Molecule weight191.66
  • Purity≥98%
  • MDL No.MFCD31742662

*For research and further manufacturing use only, not for direct human use.

(R,E)-3-(1-Methylpyrrolidin-2-yl)acrylic acid hydrochloride|CS-0110890

Structure of 2243041-69-0

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General Information

  • CAS No. 2243041-69-0
  • Cat. No. CS-0110890
  • Purity ≥98%
  • MDL No. MFCD31742662
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₄ClNO₂
  • Molecular Weight 191.66
  • Synonym(s) Pyrrolidine side chain
  • SMILES CN1[C@@H](/C=C/C(O)=O)CCC1.Cl

Description

(R,E)-3-(1-Methylpyrrolidin-2-yl)acrylic acid hydrochloride features a rigid, conjugated double bond system paired with a protonated pyrrolidine nitrogen, enhancing solubility and stability under standard conditions. This configuration enables efficient incorporation into bioactive scaffolds and facilitates downstream derivatization in medicinal chemistry applications.

Application

(R,E)-3-(1-Methylpyrrolidin-2-yl)acrylic acid hydrochloride serves as a versatile building block for synthesizing bioactive heterocycles and peptidomimetics. Its conjugated acrylate functionality enables efficient Michael additions and Diels-Alder reactions, while the pyrrolidine moiety provides a rigid, polarized scaffold with enhanced solubility and metabolic stability. The hydrochloride salt ensures excellent bench stability and ease of handling, facilitating straightforward purification and incorporation into complex molecular architectures.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   40.54
  • LogP   1.1432
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   2

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