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CS-W001157 4
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(3-Nitrophenyl)(phenyl)methanone

  • CAS No. 2243-80-3

  • Cat. No. CS-0199373
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

(3-Nitrophenyl)(phenyl)methanone|CS-0199373

Structure of 2243-80-3

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General Information

  • CAS No. 2243-80-3
  • Cat. No. CS-0199373
  • Purity ≥98%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₃H₉NO₃
  • Molecular Weight 227.22
  • Synonym(s) 3-Nitrobenzophenone
  • SMILES C1=CC=C(C=C1)C(=O)C2=CC(=CC=C2)[N+](=O)[O-]

Description

(3-Nitrophenyl)(phenyl)methanone features a para-nitro-substituted aryl ring paired with a phenyl group on the carbonyl center, delivering high electron deficiency and enhanced stability. This structural motif enables efficient integration into nitroaryl-based synthesis pathways, particularly in pharmaceutical intermediates and conjugated materials where redox activity and dipole moment are critical.

Application

(3-Nitrophenyl)(phenyl)methanone serves as a versatile aryl ketone building block in synthetic organic chemistry, enabling efficient construction of biaryl and heterocyclic scaffolds. Its ortho-directing nitro group facilitates regioselective functionalization, while the ketone moiety supports nucleophilic addition, reduction, and coupling reactions. The compound exhibits bench stability and is compatible with standard purification protocols, making it a practical choice for medicinal chemistry and process R&D workflows.

Synthesis

  • Route1

    References

    • Shen, Xiao-Bao; Gao, Ting-Ting; Lu, Jian-Mei; Shao, Li-Xiong Applied Organometallic Chemistry, 2011 , vol. 25, # 7 p. 497 - 501
  • Route2
    • null|null
      403615-35-0
    • ~80%
    • In-stock
      (3-Nitrophenyl)(phenyl)methanone|CS-0199373
      2243-80-3

    References

    • Faucher, Nicolas; Ambroise, Yves; Cintrat, Jean-Christophe; Doris, Eric; Pillon, Florence; Rousseau, Bernard Journal of Organic Chemistry, 2002 , vol. 67, # 3 p. 932 - 934
  • Route3
    • null|null
      645-00-1
    • null|null
      201230-82-2
    • null|null
      591-51-5
    • ~72%
    • In-stock
      (3-Nitrophenyl)(phenyl)methanone|CS-0199373
      2243-80-3

    References

    • Lee, Phil Ho; Lee, Sung Wook; Lee, Kooyeon Organic Letters, 2003 , vol. 5, # 7 p. 1103 - 1106

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   60.21
  • LogP   2.8258
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   3

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