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CS-W001157 4
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3-Chloro-2-methoxybenzaldehyde

  • CAS No. 223778-54-9

  • Cat. No. CS-W006013
  • Purity≥96%
  • MDL No.MFCD09999135

*For research and further manufacturing use only, not for direct human use.

3-Chloro-2-methoxybenzaldehyde|CS-W006013

Structure of 223778-54-9

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General Information

  • CAS No. 223778-54-9
  • Cat. No. CS-W006013
  • Purity ≥96%
  • MDL No. MFCD09999135
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₇ClO₂
  • Molecular Weight 170.59
  • Synonym(s) 3-Chlor-2-methoxy-benzaldehyd
  • SMILES ClC1=CC=CC(=C1OC)C=O

Description

3-Chloro-2-methoxybenzaldehyde features a chlorine atom at the meta position and a methoxy group at the ortho position relative to the aldehyde, delivering enhanced electronic modulation and solubility. This combination enables efficient incorporation into complex synthetic intermediates, particularly in pharmaceutical and agrochemical scaffold development.

Application

3-Chloro-2-methoxybenzaldehyde serves as a versatile building block in medicinal chemistry and agrochemical synthesis, offering a well-defined ortho-substituted aromatic scaffold. Its aldehyde functionality enables direct use in reductive amination, Ugi-type reactions, and Wittig olefination, while the chloro and methoxy groups provide orthogonal handles for further functionalization via Suzuki-Miyaura coupling or nucleophilic substitution. Bench-stable and amenable to purification by flash chromatography, it facilitates efficient access to complex heterocyclic systems and bioactive molecular architectures.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   26.3
  • LogP   2.1611
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   2

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