Fmoc-L-Phe(3-NH2)-OH

Name: Fmoc-L-Phe(3-NH2)-OH
Brand: ChemScene
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CAS No. 223581-75-7
Cat. No. CS-0439326
Purity≥95%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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General Information

CAS No. 223581-75-7
Cat. No. CS-0439326
Purity ≥95%
MDL No. None
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₂₄H₂₂N₂O₄
Molecular Weight 402.44
Synonym(s) (S)-2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-3-(3-aminoph
SMILES C(OC(N[C@@H](CC1=CC(N)=CC=C1)C(O)=O)=O)C2C=3C(C=4C2=CC=CC4)=CC=CC3

Description

Fmoc-L-Phe(3-NH2)-OH features a para-amino-substituted phenylalanine residue with an Fmoc protecting group, enabling efficient solid-phase peptide synthesis. The electron-rich aromatic ring and amine-functionalized side chain facilitate coupling reactions while maintaining stability under standard conditions.

Application

Fmoc-L-Phe(3-NH2)-OH serves as a key building block for the synthesis of peptide conjugates and peptidomimetics, leveraging the ortho-amino functionality for site-specific derivatization. The Fmoc group enables efficient solid-phase peptide synthesis, while the 3-aminophenyl side chain provides a versatile handle for bioconjugation and heterocycle formation. This derivative exhibits excellent bench stability, facilitates straightforward purification, and is compatible with standard coupling protocols in medicinal chemistry workflows.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

TPSA 101.65
LogP 3.8032
H_Acceptors 4
H_Donors 3
Rotatable_Bonds 6

Other Classifications

Building Blocks Functional Group Fmoc

Building Blocks Functional Group Amine

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Chemical Biology Peptide Chemistry Amine Protection

Chemical Biology Peptide Chemistry Unnatural Amino Acid Derivatives

Key Words

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Fmoc-L-Phe(3-NH2)-OH

CAS No. 223581-75-7

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