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CS-W001157 4
Total: USD 88.00

Glycine methylamide

  • CAS No. 22356-89-4

  • Cat. No. CS-0008246
  • Purity≥97%
  • MDL No.MFCD06375945

*For research and further manufacturing use only, not for direct human use.

Glycine methylamide|CS-0008246

Structure of 22356-89-4

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General Information

  • CAS No. 22356-89-4
  • Cat. No. CS-0008246
  • Purity ≥97%
  • MDL No. MFCD06375945
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₃H₈N₂O
  • Molecular Weight 88.11
  • Synonym(s) N-Methylglycinamide; N~1~-methylglycinamide hydrochloride
  • SMILES NCC(NC)=O

Description

Glycine methylamide features a terminal amide group appended to a minimal glycine backbone, offering enhanced solubility and stability in aqueous and polar organic media. This structure facilitates integration into peptide conjugates and bioactive scaffolds without compromising synthetic tractability.

Application

Glycine methylamide serves as a versatile building block in peptide synthesis and medicinal chemistry, enabling the construction of N-alkylated glycine motifs found in bioactive peptides and API scaffolds. Its amide functionality offers enhanced metabolic stability compared to free amines, while the methylamino group provides favorable solubility and synthetic handle for further derivatization. The compound exhibits excellent bench stability and compatibility with standard coupling protocols, facilitating efficient incorporation into complex molecular architectures.

Synthesis

  • Route1

    References

    • Gaeta, Alessandra; Molina-Holgado, Francisco; Kong, Xiao L.; Salvage, Sarah; Fakih, Sarah; Francis, Paul T.; Williams, Robert J.; Hider, Robert C. Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 3 p. 1285 - 1297
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    References

    • Samulis, Leopold; Tomkinson, Nicholas C.O. Tetrahedron, 2011 , vol. 67, # 23 p. 4263 - 4267
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    • In-stock
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    • In-stock
      Glycine methylamide|CS-0008246
      22356-89-4

    References

    • Rowley, Julian H.; Yau, Sze Chak; Kariuki, Benson M.; Kennedy, Alan R.; Tomkinson, Nicholas C. O. Organic and Biomolecular Chemistry, 2013 , vol. 11, # 13 p. 2198 - 2205

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   55.12
  • LogP   -1.3089
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

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