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CS-W001157 4
Total: USD 88.00

2-Hydroxy-isonicotinic acid

  • CAS No. 22282-72-0

  • Cat. No. CS-W002765
  • Purity≥97%
  • MDL No.MFCD00955759

*For research and further manufacturing use only, not for direct human use.

2-Hydroxy-isonicotinic acid|CS-W002765

Structure of 22282-72-0

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General Information

  • CAS No. 22282-72-0
  • Cat. No. CS-W002765
  • Purity ≥97%
  • MDL No. MFCD00955759
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₅NO₃
  • Molecular Weight 139.11
  • Synonym(s) None
  • SMILES O=C(C(C=CN1)=CC1=O)O

Description

2-Hydroxy-isonicotinic acid features a strategically positioned hydroxyl group adjacent to a pyridine nitrogen, enabling strong chelation with metal ions and enhancing solubility in polar solvents. This structural motif facilitates integration into coordination complexes and bioactive scaffolds, offering utility in catalysis, pharmaceutical development, and materials chemistry under standard bench conditions.

Application

2-Hydroxy-isonicotinic acid serves as a versatile building block in medicinal chemistry and synthetic organic chemistry, enabling direct access to bioactive heterocyclic scaffolds. Its ortho-hydroxypyridine motif facilitates metal chelation and enhances solubility, while the carboxylic acid group supports straightforward derivatization via amide coupling, esterification, or activation for nucleophilic substitution. The compound exhibits excellent bench stability and is compatible with standard purification methods, making it a reliable reagent for the synthesis of pharmaceutical intermediates and ligand frameworks.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   70.16
  • LogP   0.0731
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

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