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Structure of 22282-58-2
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2-Iodo-3-methylpyridine features a sterically accessible iodide at the 2-position of a methyl-substituted pyridine core, enabling efficient cross-coupling reactions under standard conditions. The electron-deficient aromatic ring facilitates palladium-catalyzed transformations, while the methyl group enhances solubility and stability in organic media. This compound serves as a key building block for functionalized heterocycles in medicinal chemistry and materials science.
2-Iodo-3-methylpyridine serves as a versatile building block in cross-coupling chemistry, enabling efficient C–C and C–heteroatom bond formation via palladium-catalyzed reactions. The iodide group exhibits high reactivity under standard Suzuki, Stille, and Negishi conditions, while the 3-methylpyridine scaffold provides orthogonal functionality for further derivatization. Bench-stable and readily purified by distillation, it functions effectively in the synthesis of biologically relevant heterocycles and pharmaceutical intermediates.
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GHS Pictogram :
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GHS No : GHS05,GHS07
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Signal Word : Danger
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UN#: 1760
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Class : 8
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Packing Group : Ⅲ
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Hazard Statements : H302-H315-H318-H335
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Precautionary Statements : P233-P260-P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P340-P362-P403-P405-P501
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Lot numbers can be found on the outside label of a product: