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CS-W001157 4
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6-Bromo-4-(6-fluoropyridin-3-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile

  • CAS No. 2222756-24-1

  • Cat. No. CS-0377694
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

6-Bromo-4-(6-fluoropyridin-3-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile|CS-0377694

Structure of 2222756-24-1

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General Information

  • CAS No. 2222756-24-1
  • Cat. No. CS-0377694
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₃H₆BrFN₄
  • Molecular Weight 317.12
  • Synonym(s) None
  • SMILES N#CC1=C2C(C3=CC=C(F)N=C3)=CC(Br)=CN2N=C1

Description

6-Bromo-4-(6-fluoropyridin-3-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile features a rigid heteroaromatic core with complementary electron-deficient sites, enabling efficient coupling in cross-coupling reactions. The bromo and nitrile groups provide orthogonal reactivity for modular synthesis. This compound serves as a key intermediate in developing kinase inhibitors and functional materials.

Application

6-Bromo-4-(6-fluoropyridin-3-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile serves as a versatile building block for constructing biologically active heterocycles, leveraging its bromo and nitrile functionalities for subsequent cross-coupling and functional group interconversions. The molecule exhibits bench stability and facilitates Pd-catalyzed reactions, enabling efficient access to complex pyrazolopyridine scaffolds relevant in medicinal chemistry and materials science.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P280-P302+P352

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Computational Chemistry Data

  • TPSA   53.98
  • LogP   3.16958
  • H_Acceptors   4
  • H_Donors   0
  • Rotatable_Bonds   1

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