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CS-W001157 4
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1-(6-Methylpyridin-3-yl)-2-[4-(methylsulfonyl)phenyl]ethanone

  • CAS No. 221615-75-4

  • Cat. No. CS-B0765
  • Purity≥98%
  • MDL No.MFCD11110696

*For research and further manufacturing use only, not for direct human use.

1-(6-Methylpyridin-3-yl)-2-[4-(methylsulfonyl)phenyl]ethanone|CS-B0765

Structure of 221615-75-4

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General Information

  • CAS No. 221615-75-4
  • Cat. No. CS-B0765
  • Purity ≥98%
  • MDL No. MFCD11110696
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₅H₁₅NO₃S
  • Molecular Weight 289.35
  • Synonym(s) ethanone, 1-(6-methyl-3-pyridinyl)-2-[4-(methylsulfonyl)phenyl]-
  • SMILES O=S(C1=CC=C(CC(C2=CC=C(C)N=C2)=O)C=C1)(C)=O

Description

This ketone features a 6-methylpyridin-3-yl group paired with a para-methylsulfonylphenyl moiety, enabling robust integration into pharmaceutical scaffolds. The molecule exhibits enhanced solubility and stability under standard conditions, facilitating efficient coupling in late-stage functionalization.

Application

1-(6-Methylpyridin-3-yl)-2-[4-(methylsulfonyl)phenyl]ethanone serves as a versatile building block in medicinal chemistry, enabling efficient construction of biaryl and heterocyclic scaffolds. Its structure combines a pyridine ring with a sulfonated aryl group, offering enhanced solubility and metabolic stability. The ketone functionality facilitates nucleophilic addition and condensation reactions, while the methylsulfonyl group provides strong electron-withdrawing character and favorable pharmacophore properties. Bench-stable and amenable to standard purification methods, it supports scalable synthesis in API development workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   64.1
  • LogP   2.21892
  • H_Acceptors   4
  • H_Donors   0
  • Rotatable_Bonds   4

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