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(4-Phenoxyphenyl)methanol

  • CAS No. 2215-78-3

  • Cat. No. CS-0142128
  • Purity≥98%
  • MDL No.MFCD01463970

*For research and further manufacturing use only, not for direct human use.

(4-Phenoxyphenyl)methanol|CS-0142128

Structure of 2215-78-3

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General Information

  • CAS No. 2215-78-3
  • Cat. No. CS-0142128
  • Purity ≥98%
  • MDL No. MFCD01463970
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₃H₁₂O₂
  • Molecular Weight 200.23
  • Synonym(s) (4-Phenoxyphenyl)methanol, 4-(Hydroxymethyl)diphenyl ether
  • SMILES OCC1=CC=C(OC2=CC=CC=C2)C=C1

Description

(4-Phenoxyphenyl)methanol features a phenolic hydroxyl group flanked by aromatic rings, delivering enhanced solubility and stability in organic media. This structure enables direct functionalization in synthesis workflows, serving as a robust scaffold for pharmaceutical intermediates and advanced materials.

Application

(4-Phenoxyphenyl)methanol serves as a versatile building block in medicinal chemistry and materials science, enabling efficient construction of biaryl ether scaffolds. Its phenolic hydroxyl group facilitates direct functionalization or derivatization, while the benzylic alcohol offers compatibility with standard protection, oxidation, and coupling protocols. The molecule exhibits good bench stability and is readily purified by chromatography or recrystallization, making it well-suited for iterative synthesis workflows.

Synthesis

  • Route1

    References

    • Eisai Co., Ltd. Patent: EP1669348 A1, 2006 ; Location in patent: Page/Page column 77 ;
  • Route2

    References

    • Takeda Pharmaceutical Company Limited Patent: EP1688138 A1, 2006 ; Location in patent: Page/Page column 104 ; EP 1688138 A1
  • Route3

    References

    • Szajnman, Sergio H.; Yan, Wen; Bailey, Brian N.; Docampo, Roberto; Elhalem, Eleonora; Rodriguez, Juan B. Journal of Medicinal Chemistry, 2000 , vol. 43, # 9 p. 1826 - 1840

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362-P501

Quality Control

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Computational Chemistry Data

  • TPSA   29.46
  • LogP   2.9712
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   3

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