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6-(Trifluoromethyl)nicotinimidamide hydrochloride

  • CAS No. 221313-11-7

  • Cat. No. CS-0156778
  • Purity≥95%
  • MDL No.MFCD01862652

*For research and further manufacturing use only, not for direct human use.

6-(Trifluoromethyl)nicotinimidamide hydrochloride|CS-0156778

Structure of 221313-11-7

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General Information

  • CAS No. 221313-11-7
  • Cat. No. CS-0156778
  • Purity ≥95%
  • MDL No. MFCD01862652
  • Storage 4°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₇ClF₃N₃
  • Molecular Weight 225.60
  • Synonym(s) 6-(trifluoromethyl)pyridine-3-carboximidamide hydrochloride
  • SMILES N=C(N)C1=CN=C(C(F)(F)F)C=C1.Cl

Description

6-(Trifluoromethyl)nicotinimidamide hydrochloride features a trifluoromethyl group at the 6-position of the nicotinimidamide core, enhancing electron-withdrawing character and metabolic stability. This bench-stable derivative integrates readily into heterocyclic synthesis, serving as a key building block for bioactive molecules in medicinal chemistry.

Application

6-(Trifluoromethyl)nicotinimidamide hydrochloride serves as a versatile building block for heterocyclic synthesis, enabling efficient access to bioactive scaffolds via coupling reactions and cyclization protocols. The trifluoromethyl group enhances metabolic stability and membrane permeability, while the imidamide functionality offers robust reactivity in amide bond formation and transition-metal-catalyzed transformations. Bench-stable and readily purified, it facilitates scalable synthesis in medicinal chemistry and process development workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS06
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H301-H317
Precautionary Statements : P261-P264-P270-P280-P302+P352-P330-P363-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   62.76
  • LogP   1.80627
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

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