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CS-W001157 4
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(3-(N-(tert-Butyl)sulfamoyl)phenyl)boronic acid

  • CAS No. 221290-14-8

  • Cat. No. CS-0102205
  • Molecule weight257.11
  • Purity≥97%
  • MDL No.MFCD06659842

*For research and further manufacturing use only, not for direct human use.

(3-(N-(tert-Butyl)sulfamoyl)phenyl)boronic acid|CS-0102205

Structure of 221290-14-8

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General Information

  • CAS No. 221290-14-8
  • Cat. No. CS-0102205
  • Purity ≥97%
  • MDL No. MFCD06659842
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₆BNO₄S
  • Molecular Weight 257.11
  • Synonym(s) 3-(tert-Butylaminosulphonyl)benzeneboronic acid
  • SMILES OB(C1=CC=CC(S(=O)(NC(C)(C)C)=O)=C1)O

Description

This boronic acid features a tert-butylsulfamoyl group at the meta position, enhancing solubility and stability. The phenylboronic moiety enables efficient Suzuki-Miyaura coupling under standard conditions. Designed for synthetic flexibility in medicinal chemistry and materials science applications.

Application

(3-(N-(tert-Butyl)sulfamoyl)phenyl)boronic acid serves as a stable, bench-ready building block for Suzuki-Miyaura cross-coupling reactions. The ortho-sulfamoyl group imparts enhanced solubility and metabolic stability, while the boronic acid functionality enables reliable coupling with aryl halides and pseudohalides under standard conditions. Its compatibility with diverse functional groups makes it particularly valuable for constructing biologically relevant heterocyclic scaffolds and pharmaceutical intermediates.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   86.63
  • LogP   -0.5568
  • H_Acceptors   4
  • H_Donors   3
  • Rotatable_Bonds   3

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