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Structure of 221202-14-8
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2-(Difluoromethoxy)-6-fluorobenzonitrile features a strategically positioned nitrile group flanked by fluorine and difluoromethoxy substituents, delivering enhanced electron-withdrawing character and metabolic stability. This trifunctional aromatic core integrates readily into pharmaceutical intermediates, offering improved solubility and robustness under standard bench conditions.
2-(Difluoromethoxy)-6-fluorobenzonitrile serves as a versatile building block in medicinal chemistry, enabling the synthesis of fluorinated aromatic scaffolds via standard coupling reactions. Its ortho-fluoro and difluoromethoxy substituents provide enhanced metabolic stability and modulated lipophilicity, while the nitrile group facilitates downstream transformations including hydrolysis to carboxylic acids or reduction to primary amines. The compound exhibits good bench stability and compatibility with common reaction conditions, supporting efficient route development for bioactive molecules.
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GHS Pictogram :
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GHS No : GHS06
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Signal Word : Danger
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UN#: 2811
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Class : 6.1
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Packing Group : Ⅲ
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Hazard Statements : H301-H311-H331
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P361+P364-P405-P501
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Lot numbers can be found on the outside label of a product: