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CS-W001157 4
Total: USD 88.00

5-Chloro-2-ethoxypyridine

  • CAS No. 22109-30-4

  • Cat. No. CS-0061649
  • Molecule weight157.60
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

5-Chloro-2-ethoxypyridine|CS-0061649

Structure of 22109-30-4

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General Information

  • CAS No. 22109-30-4
  • Cat. No. CS-0061649
  • Purity ≥97%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₈ClNO
  • Molecular Weight 157.60
  • Synonym(s) 5-Chloro-2-ethoxy-pyridine
  • SMILES CCOC1=CC=C(C=N1)Cl

Description

5-Chloro-2-ethoxypyridine serves as a key heterocyclic building block in medicinal chemistry, featuring a chlorine substituent at the 5-position and an ethoxy group at the 2-position. This electronic and steric profile enables selective coupling reactions under standard conditions, facilitating efficient integration into pharmaceutical intermediates and functional materials.

Application

5-Chloro-2-ethoxypyridine serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its well-defined electrophilic chlorine site. The ethoxy group at the 2-position provides enhanced solubility and stability compared to unsubstituted analogs, while maintaining compatibility with standard reaction conditions. This compound facilitates efficient construction of functionalized pyridine scaffolds commonly found in pharmaceutical intermediates.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319
Precautionary Statements : P264-P280-P302+P352-P362+P364

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Computational Chemistry Data

  • TPSA   22.12
  • LogP   2.1337
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   2

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