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CS-W001157 4
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5-Fluoro-1H-indole-2-carbaldehyde

  • CAS No. 220943-23-7

  • Cat. No. CS-0320669
  • Purity≥98%
  • MDL No.MFCD06800739

*For research and further manufacturing use only, not for direct human use.

5-Fluoro-1H-indole-2-carbaldehyde|CS-0320669

Structure of 220943-23-7

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General Information

  • CAS No. 220943-23-7
  • Cat. No. CS-0320669
  • Purity ≥98%
  • MDL No. MFCD06800739
  • Storage -20°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₆FNO
  • Molecular Weight None
  • Synonym(s) 5-fluoro-1H-Indole-2-carboxaldehyde
  • SMILES C1=C(C=C2C=C(C=O)NC2=C1)F

Description

5-Fluoro-1H-indole-2-carbaldehyde features a fluorinated indole core with an aldehyde at the 2-position, enabling direct coupling in cross-coupling and condensation reactions. The electron-deficient carbonyl group enhances reactivity in nucleophilic additions, while the fluorine substituent imparts metabolic stability and modulates electronic properties. This bench-stable compound serves as a key intermediate for bioactive heterocycles.

Application

5-Fluoro-1H-indole-2-carbaldehyde serves as a versatile building block for the synthesis of fluorinated heterocycles and bioactive molecules. Its aldehyde functionality enables efficient coupling reactions, including reductive amination and Wittig transformations, while the 5-fluoro substitution enhances metabolic stability and modulates electronic properties. The compound exhibits excellent bench stability and is compatible with standard purification techniques, facilitating integration into medicinal chemistry and process development workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H319
Precautionary Statements : P264-P280-P305+P351+P338-P337+P313

Quality Control

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Computational Chemistry Data

  • TPSA   32.86
  • LogP   2.1195
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   1

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