Methyl 2-(5-bromo-2-hydroxyphenyl)acetate

Name: Methyl 2-(5-bromo-2-hydroxyphenyl)acetate
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 220801-66-1
Cat. No. CS-W022786
Molecule weight245.07
Purity≥98%
MDL No.MFCD07778484

HazMat Fee +

HazMat Fee

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

The shipment is processed through FedEx Ground under the Limited Quantity option.

Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

Methyl 2-(5-bromo-2-hydroxyphenyl)acetate|CS-W022786

Structure of 220801-66-1

Size

Price

Quantity

* Please select Quantity before adding items.

General Information

CAS No. 220801-66-1
Cat. No. CS-W022786
Purity ≥98%
MDL No. MFCD07778484
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₉H₉BrO₃
Molecular Weight 245.07
Synonym(s) methyl 5-bromo-2-hydroxyphenylacetate
SMILES COC(=O)CC1=C(O)C=CC(Br)=C1

Description

Methyl 2-(5-bromo-2-hydroxyphenyl)acetate features a brominated phenolic scaffold with a pendant ester group, enabling direct functionalization in cross-coupling and derivatization workflows. The hydroxyl moiety offers sites for further modification, while the methyl ester facilitates selective transformations under mild conditions. This compound demonstrates excellent stability and solubility in common organic solvents, streamlining its integration into synthetic sequences for pharmaceutical intermediates and advanced materials.

Application

Methyl 2-(5-bromo-2-hydroxyphenyl)acetate serves as a versatile building block for the synthesis of bioactive heterocycles and pharmaceutical intermediates. The bromo and hydroxyl groups enable sequential functionalization via palladium-catalyzed coupling and directed ortho-metalation, while the ester moiety supports further transformations. Bench-stable and readily purified by column chromatography, it functions efficiently in standard cross-coupling and cyclization workflows.

Synthesis

Route1
- 67-56-1
- In-stock
  
  614-75-5
- ~94%
- In-stock
  
  220801-66-1
References
- MERCK SHARP and DOHME CORP.; MCCOMAS, Casey Cameron; LIVERTON, Nigel J.; SOLL, Richard; LI, Peng; PENG, Xuanjia; WU, Hao Patent: WO2011/106986 A1, 2011 ; Location in patent: Page/Page column 38; 39 ; WO 2011/106986 A1

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

TPSA 46.53
LogP 1.8702
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 2

Other Classifications

Building Blocks Functional Group Bromide

Building Blocks Functional Group Ester

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Key Words

220801-66-1 sigma220801-66-1 manufacturer220801-66-1 price220801-66-1 structure220801-66-1 SDSbuy 220801-66-1220801-66-1 supplier220801-66-1 uses220801-66-1 molecular weightprice of 220801-66-1220801-66-1 chemical name formula of 220801-66-1

Salutation:	*Country or Region:
*Applicant Name:	*Organization Name:
*Email Address:	Quantity:
CAS NO. :	Product Name:
Remarks:
Upload Pictures

CAS.No.		Product Name
Applicant Name *		Email Address *
Phone Number *		Organization Name*
Country or Region*		Quantity*
Remarks:

Product Name:
Cat. No.: .		CAS NO. :
Quantity:

Methyl 2-(5-bromo-2-hydroxyphenyl)acetate

CAS No. 220801-66-1

Recommended Products