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CS-W001157 4
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m-PEG12-NHS ester

  • CAS No. 2207596-93-6

  • Cat. No. CS-0114813
  • Molecule weight685.75
  • Purity≥98%
  • MDL No.MFCD13184970

*For research and further manufacturing use only, not for direct human use.

m-PEG12-NHS ester|CS-0114813

Structure of 2207596-93-6

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General Information

  • CAS No. 2207596-93-6
  • Cat. No. CS-0114813
  • Purity ≥98%
  • MDL No. MFCD13184970
  • Storage -20°C, protect from light, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₃₀H₅₅NO₁₆
  • Molecular Weight 685.75
  • Synonym(s) None
  • SMILES COCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCC(ON1C(CCC1=O)=O)=O

Description

m-PEG12-NHS ester features a mid-length polyethylene glycol spacer with a reactive NHS ester terminus, enabling efficient conjugation to primary amines under physiological conditions. This derivative offers enhanced solubility and controlled hydrophilicity for bioconjugation applications.

Application

m-PEG12-NHS ester serves as a versatile, water-soluble linker for conjugating biomolecules, enabling efficient amine coupling under physiological conditions. Its 12-atom methoxy-terminated PEG chain provides enhanced solubility and reduced non-specific binding, while the NHS ester group reacts selectively with primary amines to form stable amide bonds. Ideal for bioconjugation workflows requiring spacer length and stability, it facilitates purification and functionalization in antibody-drug conjugates and peptide modifications.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   174.44
  • LogP   -0.1873
  • H_Acceptors   16
  • H_Donors   0
  • Rotatable_Bonds   37

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