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CS-W001157 4
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1-(tert-Butyl) 2-methyl (R)-2,5-dihydro-1H-pyrrole-1,2-dicarboxylate

  • CAS No. 220652-51-7

  • Cat. No. CS-0141487
  • Purity≥97%
  • MDL No.MFCD11846998

*For research and further manufacturing use only, not for direct human use.

1-(tert-Butyl) 2-methyl (R)-2,5-dihydro-1H-pyrrole-1,2-dicarboxylate|CS-0141487

Structure of 220652-51-7

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General Information

  • CAS No. 220652-51-7
  • Cat. No. CS-0141487
  • Purity ≥97%
  • MDL No. MFCD11846998
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₁₇NO₄
  • Molecular Weight 227.26
  • Synonym(s) Boc-3,4-dehydro-D-proline methyl ester
  • SMILES CC(C)(C)OC(N1[C@H](C=CC1)C(OC)=O)=O

Description

This chiral pyrrolidine derivative features a tert-butyl group and a methyl substituent at the 2-position, conferring enhanced steric bulk and stability. The (R)-configuration at the 2,5-dihydro-1H-pyrrole core enables stereoselective transformations in asymmetric synthesis. Its bench-stable nature and compatibility with standard reaction conditions make it a reliable building block for complex heterocyclic systems.

Application

1-(tert-Butyl) 2-methyl (R)-2,5-dihydro-1H-pyrrole-1,2-dicarboxylate serves as a stable, bench-ready chiral building block for the synthesis of pyrrolidine-based scaffolds. Its tert-butyl ester and methyl substituent provide excellent functional group tolerance and ease of purification, enabling efficient transformations in asymmetric synthesis. The (R)-configured dihydropyrrole core facilitates stereoselective coupling reactions and is well-suited for constructing medicinally relevant heterocyclic frameworks.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   55.84
  • LogP   1.3349
  • H_Acceptors   4
  • H_Donors   0
  • Rotatable_Bonds   1

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