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Structure of 220239-67-8
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This trifluoromethoxy-substituted acetic acid features a highly electron-deficient aryl ring, enhancing its utility in medicinal chemistry. The ortho-trifluoromethoxy group imparts significant lipophilicity and metabolic stability, making it ideal for incorporating into bioactive scaffolds. Designed for direct use in coupling reactions, the carboxylic acid functionality enables efficient amide and ester formation under standard conditions.
2-(2-(Trifluoromethoxy)phenyl)acetic acid serves as a versatile building block in medicinal chemistry, enabling the synthesis of bioactive compounds through standard coupling reactions. Its trifluoromethoxy group imparts enhanced metabolic stability and lipophilicity, while the carboxylic acid functionality facilitates direct derivatization or incorporation into peptide-like scaffolds. The compound exhibits excellent bench stability and is readily purified by recrystallization, supporting its use in scalable synthetic workflows.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H315-H319-H335
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Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501
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Lot numbers can be found on the outside label of a product: