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CS-W001157 4
Total: USD 88.00

4-Fluoro-3-(trifluoromethyl)phenylacetic acid

  • CAS No. 220227-47-4

  • Cat. No. CS-W013122
  • Purity≥98%
  • MDL No.MFCD00061190

*For research and further manufacturing use only, not for direct human use.

4-Fluoro-3-(trifluoromethyl)phenylacetic acid|CS-W013122

Structure of 220227-47-4

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General Information

  • CAS No. 220227-47-4
  • Cat. No. CS-W013122
  • Purity ≥98%
  • MDL No. MFCD00061190
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₆F₄O₂
  • Molecular Weight 222.14
  • Synonym(s) [4-fluoro-3-(trifluoromethyl)phenyl]acetic acid
  • SMILES OC(=O)CC1=CC(=C(F)C=C1)C(F)(F)F

Description

4-Fluoro-3-(trifluoromethyl)phenylacetic acid features a fluorinated aromatic ring paired with a trifluoromethyl group, delivering enhanced metabolic stability and lipophilicity. This electron-deficient arylacetic acid integrates readily into bioactive scaffolds, serving as a key building block in medicinal chemistry for targeted kinase inhibitors and CNS-active compounds.

Application

4-Fluoro-3-(trifluoromethyl)phenylacetic acid serves as a valuable building block for bioactive molecule synthesis, offering enhanced metabolic stability and lipophilicity due to the combined electron-withdrawing effects of the fluorine and trifluoromethyl groups. Its carboxylic acid functionality enables direct derivatization or coupling reactions, while the aryl side chain exhibits robust bench stability and compatibility with standard synthetic protocols, facilitating efficient access to pharmaceutical intermediates and functionalized heterocycles.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P302+P352

Quality Control

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Computational Chemistry Data

  • TPSA   37.3
  • LogP   2.4716
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   2

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