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Structure of 220141-71-9
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3,5-Difluorobenzyl chloride features a benzyl chloride moiety substituted with fluorine atoms at the 3 and 5 positions, delivering enhanced reactivity and stability. This electron-deficient aryl chloride integrates readily into synthetic pathways requiring selective functionalization. The difluoro substitution improves metabolic resistance and modulates lipophilicity, making it valuable for medicinal chemistry applications.
3,5-Difluorobenzyl chloride serves as a versatile electrophilic building block in medicinal chemistry and synthetic organic chemistry. Its ortho-fluorine substituents enhance metabolic stability while enabling selective functionalization. The chloromethyl group facilitates efficient nucleophilic substitution reactions, including amine coupling and heterocycle formation, with excellent bench stability and straightforward purification. This reagent is particularly valuable for constructing fluorinated aromatic scaffolds in API development.
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GHS Pictogram :
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GHS No : GHS05
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Signal Word : Danger
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UN#: 1760
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Class : 8
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Packing Group : Ⅱ
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Hazard Statements : H314
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Precautionary Statements : P260-P264-P280-P301+P330+P331-P304+P340-P363-P405-P501
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Lot numbers can be found on the outside label of a product: