4-Amino-5-chloro-2-methoxy-N-(piperidin-4-ylmethyl)benzamide

Name: 4-Amino-5-chloro-2-methoxy-N-(piperidin-4-ylmethyl)benzamide
Brand: ChemScene
Availability: InStock
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CAS No. 220032-26-8
Cat. No. CS-0150443
Purity≥98%
MDL No.MFCD17212472

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
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4-Amino-5-chloro-2-methoxy-N-(piperidin-4-ylmethyl)benzamide|CS-0150443

Structure of 220032-26-8

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Description

This benzamide derivative features a piperidin-4-ylmethyl substituent that enhances solubility and modulates bioavailability. The para-amino and ortho-chloro groups establish electron-deficient character, while the methoxy moiety contributes to steric and electronic tuning. It serves as a key intermediate in medicinal chemistry campaigns targeting kinase inhibitors and CNS-active compounds.

Application

4-Amino-5-chloro-2-methoxy-N-(piperidin-4-ylmethyl)benzamide serves as a versatile scaffold in medicinal chemistry, enabling the construction of diverse heterocyclic systems and bioactive molecules. The molecule combines a chlorinated aniline core with a methoxy group and a piperidinylmethyl amide, offering orthogonal functional handles for downstream derivatization. Its bench-stable nature and compatibility with standard coupling and cyclization protocols facilitate efficient synthesis of targeted compounds.

General Information

CAS No. 220032-26-8
Cat. No. CS-0150443
Purity ≥98%
MDL No. MFCD17212472
Storage 4°C, sealed storage, away from moisture and light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₄H₂₀ClN₃O₂
Molecular Weight 297.78
Synonym(s) 4-Amino-N-((4-piperidinyl)methyl)-5-chloro-2-methoxybenzamide
SMILES COC1=CC(N)=C(Cl)C=C1C(NCC2CCNCC2)=O

Computational Chemistry Data

TPSA 76.38
LogP 1.6602
H_Acceptors 4
H_Donors 3
Rotatable_Bonds 4

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Other Classifications

Building Blocks Functional Group Amide

Building Blocks Skeleton Aliphatic heterocycle compounds Piperidine compounds

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Key Words

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4-Amino-5-chloro-2-methoxy-N-(piperidin-4-ylmethyl)benzamide

CAS No. 220032-26-8

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