Tel:

Email:

EN
Cat. No. Size / Unit Price Qty
CS-W001157 4
Total: USD 88.00

tert-Butyl (1,2,3,4-tetrahydroquinolin-3-yl)carbamate

  • CAS No. 219862-14-3

  • Cat. No. CS-W006318
  • Purity≥98%
  • MDL No.MFCD02181058

*For research and further manufacturing use only, not for direct human use.

tert-Butyl (1,2,3,4-tetrahydroquinolin-3-yl)carbamate|CS-W006318

Structure of 219862-14-3

Please choose your location and provide accurate information for you
Size Stock
Price Quantity

* Please select Quantity before adding items.

General Information

  • CAS No. 219862-14-3
  • Cat. No. CS-W006318
  • Purity ≥98%
  • MDL No. MFCD02181058
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₄H₂₀N₂O₂
  • Molecular Weight 248.32
  • Synonym(s) (1,2,3,4-Tetrahydro-quinolin-3-yl)-carbamic acid tert-butyl ester
  • SMILES O=C(NC1CNC2=C(C1)C=CC=C2)OC(C)(C)C

Description

tert-Butyl (1,2,3,4-tetrahydroquinolin-3-yl)carbamate serves as a stable, bench-ready nitrogen protecting group for the synthesis of tetrahydroquinoline-based pharmaceutical intermediates. The carbamate moiety enables selective deprotection under mild acidic conditions, preserving sensitive functional groups. This derivative combines enhanced solubility with robust stability during storage and handling.

Application

tert-Butyl (1,2,3,4-tetrahydroquinolin-3-yl)carbamate serves as a versatile nitrogen protecting group in synthetic organic chemistry, enabling selective functionalization at the 3-position of the tetrahydroquinoline core. Its stability under a range of reaction conditions facilitates downstream transformations, including palladium-catalyzed couplings and reductive deprotection. The carbamate moiety offers excellent solubility and ease of purification, making it well-suited for medicinal chemistry campaigns and API intermediate synthesis.

Synthesis

  • Route1
    • Tert-butyl N-(quinolin-3-yl)carbamate|CS-0754271
      219862-13-2
    • ~75%
    • In-stock
      tert-Butyl (1,2,3,4-tetrahydroquinolin-3-yl)carbamate|CS-W006318
      219862-14-3

    References

    • Sun, Chongqing; Ewing, William R.; Huang, Yanting; Pendri, Annapurna; Gerritz, Samuel; Ellsworth, Bruce A.; Murugesan, Natesan Patent: US2006/160850 A1, 2006 ; Location in patent: Page/Page column 9 ; US 20060160850 A1
  • Route2
    • null|null
      890839-20-0
    • ~%
    • In-stock
      tert-Butyl (1,2,3,4-tetrahydroquinolin-3-yl)carbamate|CS-W006318
      219862-14-3

    References

    • US2008/153871 A1, ; Page/Page column 30 ;
  • Route3
    • null|null
      580-17-6
    • ~%
    • In-stock
      tert-Butyl (1,2,3,4-tetrahydroquinolin-3-yl)carbamate|CS-W006318
      219862-14-3

    References

    • Bioorganic and Medicinal Chemistry Letters, , vol. 15, # 7 p. 1895 - 1899

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

  • TPSA   50.36
  • LogP   2.5479
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   1

Other Classifications

Recently Viewed Products

Leave US a Message
Upload Pictures

Key Words

  • 219862-14-3 sigma219862-14-3 manufacturer219862-14-3 price219862-14-3 structure219862-14-3 SDSbuy 219862-14-3219862-14-3 supplier219862-14-3 uses219862-14-3 molecular weightprice of 219862-14-3219862-14-3 chemical name formula of 219862-14-3
This product is not sold in the region.
Confirm
How to get a Lot Number

Lot numbers can be found on the outside label of a product:

ChemScene Label