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CS-W001157 4
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2-(Methyl(phenyl)amino)acetic acid hydrochloride

  • CAS No. 21911-75-1

  • Cat. No. CS-0151259
  • Purity≥98%
  • MDL No.MFCD13186269

*For research and further manufacturing use only, not for direct human use.

2-(Methyl(phenyl)amino)acetic acid hydrochloride|CS-0151259

Structure of 21911-75-1

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General Information

  • CAS No. 21911-75-1
  • Cat. No. CS-0151259
  • Purity ≥98%
  • MDL No. MFCD13186269
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₂ClNO₂
  • Molecular Weight 201.65
  • Synonym(s) N-Phenyl-N-Methylglycine Hydrochloride
  • SMILES CN(CC(=O)O)C1=CC=CC=C1.Cl

Description

This hydrochloride salt features a methyl(phenyl)amino group attached to a carboxylic acid-bearing acetic acid scaffold, offering enhanced solubility and stability under standard handling conditions. The protonated amine facilitates efficient coupling in peptide synthesis and enables straightforward isolation and purification.

Application

2-(Methyl(phenyl)amino)acetic acid hydrochloride serves as a versatile building block for synthesizing amino acid derivatives and bioactive heterocycles. Its pendant aniline moiety enables facile functionalization, while the carboxylic acid group facilitates peptide coupling and salt formation. The hydrochloride form enhances solubility and stability in aqueous and polar organic media, supporting robust handling in standard synthetic workflows.

Synthesis

  • Route1
    • null|null
      20059-60-3
    • ~73%
    • In-stock
      2-(Methyl(phenyl)amino)acetic acid hydrochloride|CS-0151259
      21911-75-1

    References

    • Dolle, Roland E.; Chu, Guo-Hua; Gu, Minghua Patent: US2005/107355 A1, 2005 ; Location in patent: Page/Page column 29-30 ;
  • Route2
    • Ethyl N-methyl-N-phenylglycinate|CS-0600965
      21911-74-0
    • ~81%
    • In-stock
      2-(Methyl(phenyl)amino)acetic acid hydrochloride|CS-0151259
      21911-75-1

    References

    • Brady, William T.; Gu, Yi Qi Journal of Organic Chemistry, 1989 , vol. 54, # 12 p. 2834 - 2838
  • Route3

    References

    • Oechslin Annales de Chimie (Cachan, France), 1914 , vol. <9>1, p. 244

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   40.54
  • LogP   1.6292
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   3

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