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Structure of 217959-85-8
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This thiophene-based carboxylic acid features a trifluoromethyl group enhancing electron deficiency and metabolic stability, while the 3-hydroxy substituent enables direct functionalization or hydrogen bonding. The conjugated system supports integration into bioactive scaffolds and advanced materials, offering improved solubility and reactivity under standard bench conditions.
3-Hydroxy-5-(trifluoromethyl)thiophene-2-carboxylic acid serves as a versatile building block in medicinal chemistry, enabling the synthesis of bioactive heterocycles through standard functional group manipulations. Its trifluoromethyl group enhances metabolic stability and lipophilicity, while the carboxylic acid and hydroxyl functionalities provide orthogonal handles for derivatization. The compound exhibits bench stability and facilitates efficient purification, supporting scalable synthesis workflows.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P233-P261-P280-P301+P330+P331-P302+P352-P304+P340
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Lot numbers can be found on the outside label of a product: