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Total: USD 88.00

3-Methoxy-2-(trimethylsilyl)phenyl trifluoromethanesulfonate

  • CAS No. 217813-03-1

  • Cat. No. CS-0182182
  • Purity≥95%
  • MDL No.MFCD10566916

*For research and further manufacturing use only, not for direct human use.

3-Methoxy-2-(trimethylsilyl)phenyl trifluoromethanesulfonate|CS-0182182

Structure of 217813-03-1

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General Information

  • CAS No. 217813-03-1
  • Cat. No. CS-0182182
  • Purity ≥95%
  • MDL No. MFCD10566916
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₁₅F₃O₄SSi
  • Molecular Weight None
  • Synonym(s) Trifluoromethanesulfonic Acid 3-Methoxy-2-(trimethylsilyl)phenyl Ester
  • SMILES O=S(C(F)(F)F)(OC1=CC=CC(OC)=C1[Si](C)(C)C)=O

Description

3-Methoxy-2-(trimethylsilyl)phenyl trifluoromethanesulfonate delivers a robust, bench-stable platform for electrophilic aromatic substitution. The triflate group enables efficient arylation under mild conditions, while the trimethylsilyl moiety enhances solubility and stability. This reagent streamlines access to complex phenolic architectures in synthetic workflows.

Application

3-Methoxy-2-(trimethylsilyl)phenyl trifluoromethanesulfonate serves as a versatile silyl-protected phenol derivative, enabling selective ortho-functionalization in complex molecule synthesis. The triflate group facilitates palladium-catalyzed cross-coupling reactions, while the trimethylsilyl moiety provides stability and orthogonal deprotection. Its bench-stable nature and compatibility with diverse reaction conditions make it ideal for iterative synthetic strategies in medicinal chemistry and natural product synthesis.

Safety Information

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GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 3265
Class : 8
Packing Group : Ⅱ
Hazard Statements : H290-H314
Precautionary Statements : P234-P264-P280-P301+P330+P331-P304+P340-P363-P390-P405-P406-P501

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Computational Chemistry Data

  • TPSA   52.6
  • LogP   2.4688
  • H_Acceptors   4
  • H_Donors   0
  • Rotatable_Bonds   4

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