Tel:

Email:

EN
Cat. No. Size / Unit Price Qty
CS-W001157 4
Total: USD 88.00

1-(Difluoromethyl)-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

  • CAS No. 2173194-53-9

  • Cat. No. CS-0141598
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

1-(Difluoromethyl)-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole|CS-0141598

Structure of 2173194-53-9

Please choose your location and provide accurate information for you
Size Stock
Price Quantity

* Please select Quantity before adding items.

General Information

  • CAS No. 2173194-53-9
  • Cat. No. CS-0141598
  • Purity ≥98%
  • MDL No. None
  • Storage -20°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₅BF₂N₂O₂
  • Molecular Weight 244.05
  • Synonym(s) 1-(Difluoromethyl)pyrazole-3-boronic Acid Pinacol Ester
  • SMILES CC1(C)C(C)(C)OB(C2=NN(C(F)F)C=C2)O1

Description

1-(Difluoromethyl)-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole integrates a difluoromethyl group and a stable boronate handle, enabling direct coupling in Suzuki-Miyaura reactions. The tetramethyl-substituted dioxaborolane enhances shelf life and moisture tolerance, while the pyrazole core provides a rigid, electron-deficient scaffold for diverse heterocyclic synthesis under standard conditions.

Application

1-(Difluoromethyl)-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole serves as a versatile boronate building block for Suzuki-Miyaura coupling reactions. The difluoromethyl group imparts enhanced metabolic stability and modulates electronic properties, while the pinacol boronate enables robust coupling under mild conditions. This reagent exhibits excellent bench stability, tolerates a range of functional groups, and facilitates efficient construction of pyrazole-based pharmacophores in medicinal chemistry and materials science applications.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05,GHS07
Signal Word : Danger
UN#: 1759
Class : 8
Packing Group : Ⅲ
Hazard Statements : H315-H318-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

  • TPSA   36.28
  • LogP   1.5774
  • H_Acceptors   4
  • H_Donors   0
  • Rotatable_Bonds   2

Other Classifications

Recently Viewed Products

Leave US a Message
Upload Pictures

Key Words

  • 2173194-53-9 sigma2173194-53-9 manufacturer2173194-53-9 price2173194-53-9 structure2173194-53-9 SDSbuy 2173194-53-92173194-53-9 supplier2173194-53-9 uses2173194-53-9 molecular weightprice of 2173194-53-92173194-53-9 chemical name formula of 2173194-53-9
This product is not sold in the region.
Confirm
How to get a Lot Number

Lot numbers can be found on the outside label of a product:

ChemScene Label