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Structure of 2173052-69-0
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This difluoropyrrolidine derivative features a sterically constrained, bench-stable scaffold with enhanced membrane permeability. The dihydrochloride salt form improves solubility and handling in aqueous workflows. It integrates efficiently into bioactive molecule synthesis, particularly for CNS-targeted compounds requiring metabolic stability and favorable pharmacokinetic profiles.
[(2R)-4,4-Difluoro-1-methylpyrrolidin-2-yl]methanamine dihydrochloride serves as a conformationally constrained, fluorinated aminoalkyl building block for medicinal chemistry. Its rigid pyrrolidine core enhances metabolic stability and modulates basicity, while the difluoro substitution improves membrane permeability. The dihydrochloride salt form ensures excellent solubility and bench stability, facilitating straightforward handling in amide couplings, reductive aminations, and macrocyclization reactions.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
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Lot numbers can be found on the outside label of a product: