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[(2R)-4,4-Difluoro-1-methylpyrrolidin-2-yl]methanamine dihydrochloride

  • CAS No. 2173052-69-0

  • Cat. No. CS-0184310
  • Molecule weight223.09
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

[(2R)-4,4-Difluoro-1-methylpyrrolidin-2-yl]methanamine dihydrochloride|CS-0184310

Structure of 2173052-69-0

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General Information

  • CAS No. 2173052-69-0
  • Cat. No. CS-0184310
  • Purity ≥97%
  • MDL No. None
  • Storage Store at room temperature, keep dry and cool
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₁₄Cl₂F₂N₂
  • Molecular Weight 223.09
  • Synonym(s) None
  • SMILES NC[C@@H]1N(C)CC(F)(F)C1.[H]Cl.[H]Cl

Description

This difluoropyrrolidine derivative features a sterically constrained, bench-stable scaffold with enhanced membrane permeability. The dihydrochloride salt form improves solubility and handling in aqueous workflows. It integrates efficiently into bioactive molecule synthesis, particularly for CNS-targeted compounds requiring metabolic stability and favorable pharmacokinetic profiles.

Application

[(2R)-4,4-Difluoro-1-methylpyrrolidin-2-yl]methanamine dihydrochloride serves as a conformationally constrained, fluorinated aminoalkyl building block for medicinal chemistry. Its rigid pyrrolidine core enhances metabolic stability and modulates basicity, while the difluoro substitution improves membrane permeability. The dihydrochloride salt form ensures excellent solubility and bench stability, facilitating straightforward handling in amide couplings, reductive aminations, and macrocyclization reactions.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   29.26
  • LogP   1.1281
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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