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CS-W001157 4
Total: USD 88.00

3-(1-(tert-Butoxycarbonyl)pyrrolidin-3-yl)propiolic acid

  • CAS No. 2172597-24-7

  • Cat. No. CS-0377592
  • Purity≥95%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

3-(1-(tert-Butoxycarbonyl)pyrrolidin-3-yl)propiolic acid|CS-0377592

Structure of 2172597-24-7

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General Information

  • CAS No. 2172597-24-7
  • Cat. No. CS-0377592
  • Purity ≥95%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₁₇NO₄
  • Molecular Weight 239.27
  • Synonym(s) None
  • SMILES O=C(N1CC(C#CC(O)=O)CC1)OC(C)(C)C

Description

This propiolic acid derivative features a tert-butoxycarbonyl-protected pyrrolidine moiety, enabling direct incorporation into peptide-based scaffolds. The alkyne functionality supports efficient copper-catalyzed cycloadditions, facilitating rapid conjugation in bioorthogonal labeling and chemical biology applications.

Application

3-(1-(tert-Butoxycarbonyl)pyrrolidin-3-yl)propiolic acid serves as a versatile building block for synthesizing pyrrolidine-containing heterocycles and bioactive scaffolds. The propiolic acid functionality enables efficient Sonogashira coupling, cyclization, and conjugate addition reactions, while the Boc-protected amine ensures stability and ease of purification. This reagent facilitates straightforward access to complex molecular architectures under standard laboratory conditions.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   66.84
  • LogP   1.3314
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   0

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