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Structure of 216766-12-0
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5-Hydroxy-2-trifluoromethylpyridine features a trifluoromethyl group at the pyridine ring's 2-position and a hydroxyl substituent at the 5-position, creating a uniquely electron-deficient heterocyclic scaffold. This configuration enhances its utility in coupling reactions and as a building block for bioactive molecules. The molecule exhibits improved solubility and stability compared to non-fluorinated analogs.
5-Hydroxy-2-trifluoromethylpyridine serves as a versatile building block for the synthesis of functionalized heterocycles and pharmaceutical intermediates. The hydroxyl group enables direct derivatization via etherification, esterification, or transition-metal-catalyzed coupling, while the trifluoromethyl moiety imparts enhanced metabolic stability and lipophilicity. Its bench-stable nature and compatibility with standard protecting group strategies facilitate efficient multistep synthesis in medicinal chemistry workflows.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: