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CS-W001157 4
Total: USD 88.00

(3-Hydroxy-4-methylphenyl)boronic acid

  • CAS No. 216019-35-1

  • Cat. No. CS-0083482
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

(3-Hydroxy-4-methylphenyl)boronic acid|CS-0083482

Structure of 216019-35-1

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General Information

  • CAS No. 216019-35-1
  • Cat. No. CS-0083482
  • Purity ≥97%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₉BO₃
  • Molecular Weight 151.96
  • Synonym(s) 3-Hydroxy-4-methylphenylboronic acid
  • SMILES OB(C1=CC=C(C)C(O)=C1)O

Description

This boronate moiety features a phenolic hydroxyl group flanked by a methyl substituent, enabling selective coupling in Suzuki-Miyaura reactions. The ortho-hydroxy functionality enhances stability and solubility in polar solvents while maintaining compatibility with standard reaction conditions.

Application

(3-Hydroxy-4-methylphenyl)boronic acid serves as a versatile building block in Suzuki-Miyaura cross-coupling reactions, enabling efficient C–C bond formation under mild conditions. The ortho-hydroxyl group enhances regioselectivity and facilitates chelation-controlled coupling, while the methyl substituent provides steric and electronic modulation. Its bench-stable nature and compatibility with diverse functional groups make it ideal for constructing substituted phenolic scaffolds in medicinal chemistry and materials science applications.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P405-P501

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Computational Chemistry Data

  • TPSA   60.69
  • LogP   -0.61958
  • H_Acceptors   3
  • H_Donors   3
  • Rotatable_Bonds   1

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