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CS-W001157 4
Total: USD 88.00

Azido-PEG12-acid

  • CAS No. 2152679-71-3

  • Cat. No. CS-0115264
  • Purity≥96%
  • MDL No.MFCD21363301

*For research and further manufacturing use only, not for direct human use.

Azido-PEG12-acid|CS-0115264

Structure of 2152679-71-3

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General Information

  • CAS No. 2152679-71-3
  • Cat. No. CS-0115264
  • Purity ≥96%
  • MDL No. MFCD21363301
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₂₇H₅₃N₃O₁₄
  • Molecular Weight 643.72
  • Synonym(s) None
  • SMILES OC(CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCN=[N+]=[N-])=O

Description

Azido-PEG12-acid is a bifunctional linker featuring a terminal azide group and a carboxylic acid moiety separated by a 12-ethylene glycol unit. This hydrophilic spacer enhances solubility while enabling bioorthogonal conjugation via strain-promoted or copper-catalyzed azide-alkyne cycloaddition. The acid functionality facilitates amide bond formation with amines, streamlining the synthesis of targeted probes and functionalized biomolecules under standard conditions.

Application

Azido-PEG12-acid serves as a versatile bifunctional linker for bioconjugation and polymer chemistry, combining a terminal azide group with a carboxylic acid functionality. The PEG12 spacer provides enhanced solubility and reduced aggregation, while enabling efficient copper-catalyzed azide-alkyne cycloaddition (CuAAC) and amide coupling reactions. Its stability under standard bench conditions and compatibility with diverse functional groups make it ideal for constructing site-specific conjugates and functionalized materials in drug delivery and diagnostics.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   196.82
  • LogP   0.9706
  • H_Acceptors   14
  • H_Donors   1
  • Rotatable_Bonds   39

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