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CS-W001157 4
Total: USD 88.00

tert-Butyl 4-carbamothioylpiperidine-1-carboxylate

  • CAS No. 214834-18-1

  • Cat. No. CS-W004912
  • Purity≥95%
  • MDL No.MFCD02180954

*For research and further manufacturing use only, not for direct human use.

tert-Butyl 4-carbamothioylpiperidine-1-carboxylate|CS-W004912

Structure of 214834-18-1

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General Information

  • CAS No. 214834-18-1
  • Cat. No. CS-W004912
  • Purity ≥95%
  • MDL No. MFCD02180954
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₂₀N₂O₂S
  • Molecular Weight 244.35
  • Synonym(s) N-BOC-piperidine-4-carbothioamide
  • SMILES O=C(N1CCC(C(N)=S)CC1)OC(C)(C)C

Description

tert-Butyl 4-carbamothioylpiperidine-1-carboxylate is a bench-stable, moisture-tolerant building block featuring a piperidine core with dual protecting groups. The carbamothioyl moiety enables selective functionalization, while the tert-butyl ester facilitates straightforward deprotection under mild acidic conditions. This compound streamlines access to sulfonamide and thiourea derivatives in synthetic and medicinal chemistry workflows.

Application

tert-Butyl 4-carbamothioylpiperidine-1-carboxylate serves as a versatile building block in medicinal chemistry, enabling the construction of thioamide-containing heterocycles and peptide mimetics. The carbamothioyl group offers enhanced stability and orthogonal reactivity, facilitating selective transformations under mild conditions. Its tert-butyl ester moiety supports straightforward deprotection, while the piperidine scaffold provides a rigid, bioactive core compatible with diverse downstream functionalizations.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   55.56
  • LogP   1.9196
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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