Fmoc-D-Lys(Aloc)-OH

Name: Fmoc-D-Lys(Aloc)-OH
Brand: ChemScene
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CAS No. 214750-75-1
Cat. No. CS-W022726
Purity≥95%
MDL No.MFCD00798639

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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General Information

CAS No. 214750-75-1
Cat. No. CS-W022726
Purity ≥95%
MDL No. MFCD00798639
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₂₅H₂₈N₂O₆
Molecular Weight 452.50
Synonym(s) None
SMILES O=C(O)[C@H](NC(OCC1C2=C(C3=C1C=CC=C3)C=CC=C2)=O)CCCCNC(OCC=C)=O

Description

Fmoc-D-Lys(Aloc)-OH features a D-lysine residue protected with both Fmoc and Aloc groups, enabling orthogonal deprotection during solid-phase peptide synthesis. The Aloc moiety offers selective removal under mild photocleavage conditions, preserving other functional groups. This dual protection strategy enhances synthetic flexibility in complex peptide assembly, particularly for multi-protected sequences requiring sequential deprotection.

Application

Fmoc-D-Lys(Aloc)-OH serves as a key building block in the synthesis of peptide-based therapeutics and combinatorial libraries. The Fmoc group enables efficient N-terminal protection in solid-phase peptide synthesis, while the Aloc (alloc) side chain protection offers orthogonal deprotection under mild palladium(0) conditions. This dual functionality facilitates selective modification and simplifies purification in complex sequences, making it ideal for site-specific conjugation and multi-step peptide assembly.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 113.96
LogP 4.0608
H_Acceptors 5
H_Donors 3
Rotatable_Bonds 11

Other Classifications

Bioactive Molecules Peptides

Life Science Amino Acids and their Derivatives Lysine and derivatives

Building Blocks Functional Group Fmoc

Chemical Biology Peptide Chemistry Amine Protection

Chemical Biology Peptide Chemistry Unnatural Amino Acid Derivatives

Key Words

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Fmoc-D-Lys(Aloc)-OH

CAS No. 214750-75-1

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