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CS-W001157 4
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Methyl 5-(chloromethyl)furan-2-carboxylate

  • CAS No. 2144-37-8

  • Cat. No. CS-W017480
  • Molecule weight174.58
  • Purity≥98%
  • MDL No.MFCD00020922

*For research and further manufacturing use only, not for direct human use.

Methyl 5-(chloromethyl)furan-2-carboxylate|CS-W017480

Structure of 2144-37-8

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General Information

  • CAS No. 2144-37-8
  • Cat. No. CS-W017480
  • Purity ≥98%
  • MDL No. MFCD00020922
  • Storage -20°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₇ClO₃
  • Molecular Weight 174.58
  • Synonym(s) Methyl 5-(chloromethyl)-2-furoate
  • SMILES COC(=O)C1=CC=C(CCl)O1

Description

Methyl 5-(chloromethyl)furan-2-carboxylate features a reactive chloromethyl group flanked by a furan ring and ester functionality, enabling direct functionalization in late-stage diversification. This bench-stable reagent integrates readily into synthetic sequences requiring site-specific alkylation or cross-coupling transformations under mild conditions.

Application

Methyl 5-(chloromethyl)furan-2-carboxylate serves as a versatile building block in synthetic organic chemistry, enabling efficient functionalization at the furan C5 position. The chloromethyl group facilitates nucleophilic substitution reactions, while the ester functionality supports downstream transformations such as hydrolysis or reduction. Its bench-stable nature and compatibility with diverse reaction conditions make it valuable for constructing heterocyclic scaffolds and complex molecular architectures in medicinal chemistry and process development workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 1759
Class : 8
Packing Group : Ⅱ
Hazard Statements : H314
Precautionary Statements : P260-P264-P280-P301+P330+P331-P304+P340-P363-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   39.44
  • LogP   1.805
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   2

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